Table 4.

Pharmacological features of nicotinic responses in VTA DAergic neurons – antagonists

		Peak						Area
		DHβE (μm)		MEC (μm)		MLA (nm)		DHβE (μm)		MEC (μm)		MLA (nm)
Type	n	IC50	Hill	IC50	Hill	IC50	Hill	IC50	Hill	IC50	Hill	IC50	Hill
ID	6	28	1.0	1.2	1.1	17	0.6	5.3	0.9	0.9	0.9	8.2	0.4
IID	6	62	0.7	21	0.9	130	0.7	1.2	0.6	0.4	0.6	156	0.5
IIID	4	> 100	0.3	0.9	0.7	NE	NE	> 100	0.4	0.1	1.2	NE	NE

Agonist used for these experiments was 1 mm ACh. All antagonists were coapplied with ACh. NE: no effect.