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. 2008 Dec 1;587(Pt 2):461–475. doi: 10.1113/jphysiol.2008.161760

Figure 5. Effects of antagonism of GABAA receptors in the CVLM on the sympathetic response to hypoxia and cyanide.

Figure 5

A, inhalation of hypoxic air or injection of CN increased SNA before and after bilateral microinjection of bicuculline into the CVLM. Microinjection of bicuculline into the CVLM decreases SNA and AP (Table 2). B, prior to antagonism of GABAA receptors in the CVLM, hypoxia significantly elevates SNA with respiratory-related bursts. C, after bicuculline, the sympathetic response to hypoxia is significantly reduced. The hypoxia-induced (D) or CN-induced (E) increases in SNA were greatly blunted by antagonism of GABAA receptors in the CVLM. *Significant difference from control values.