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. 2008 Dec 8;587(Pt 3):597–610. doi: 10.1113/jphysiol.2008.165902

Figure 8. Respiratory modulation of tSNA does not change after arterial baroreceptor denervation in SH rats.

Figure 8

A and B, traces of integrated phrenic nerve activity (∫PNA), heart rate (HR) and integrated thoracic sympathetic nerve activity (∫tSNA) during a baroreflex challenge (A) and a chemoreflex challenge (B) before (top) and after (bottom) sectioning the glossopharyngeal and vagal nerves in an SH rat. A, a bolus of 10 μg phenylephrine (PE, i.a.) together with an increase in flow to increase perfusion pressure (PP) evoked sympathoinhibition in the intact state but this response was lost after denervation (lower panel). Phrenic-triggered averages of tSNA (A') show that the pattern of respiratory modulation is not changed with barodenervation in SH rats; the peak of tSNA remains in the inspiratory period as observed in intact 5 week old SH rat. B, a bolus of 50 μl sodium cyanide (NaCN, 0.05%, i.a.) evoked sympathoexcitation and an increased respiratory rate in the intact state. This peripheral chemoreflex response was also lost after sectioning the glossopharyngeal and vagal nerves.