Table 3.
Fetal organ blood flows and ECoG state
| Baseline | Hypoglycaemia | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C1 | PI50 | C2 | PI40 | L | All | C1 | PI50 | C2 | PI40 | L | All | |
| Organ blood flow (mL min−1 (100 g)−1) | ||||||||||||
| Pancreas | 89.6 | 90.2 | 57.8 | 74.3 | 81.9 | 78.0 | 84.6 | 72.7 | 47.2 | 94.1 | 62.6 | 72.3 |
| ± 8.5 | ± 19.7 | ± 7.2 | ± 8.4 | ± 16.7 | ± 5.7 | ± 18.3 | ± 14.1 | ± 4.4 | ± 14.1 | ± 13.2 | ± 6.3 | |
| Right adrenal | 493.8 | 438.0 | 393.4 | 711.1 | 527.3 | 510.1 | 488.6 | 479.9 | 487.7 | 1004.4 | 616.9 | 625.6 |
| ± 70.5 | ± 79.8 | ± 73.8 | ± 182.0 | ± 139.3 | ± 56.2 | ± 82.3 | ± 85.6 | ± 62.8 | ±280.5 | ± 130.4 | ± 78.8† | |
| Right kidney | 185.1 | 216.2 | 200.7 | 231.7 | 240.7 | 212.3 | 177.6 | 196.1 | 194.8 | 257.4 | 203.6 | 206.8 |
| ± 8.7 | ± 34.1 | ± 18.5 | ± 21.5 | ± 33.1 | ± 10.5 | ± 15.6 | ± 33.3 | ± 10.1 | ± 26.9 | ± 16.7 | ± 10.6 | |
| Left liver | 6.0 | 6.2 | 2.8 | 3.9 | 5.0 | 4.7 | 4.9 | 4.9 | 2.6 | 3.3 | 3.4 | 3.7 |
| ± 1.2 | ± 1.4 | ± 0.6 | ± 0.7 | ± 1.6 | ± 0.5 | ± 1.1 | ± 1.3 | ± 0.5 | ± 0.2 | ± 0.8 | ± 0.4† | |
| Right liver | 5.8 | 4.9 | 2.9 | 4.3 | 4.8 | 4.6 | 5.3 | 4.6 | 2.9 | 4.2 | 3.5 | 4.0 |
| ± 1.6 | ± 1.2 | ± 0.5 | ± 0.7 | ± 1.9 | ± 0.5 | ± 1.1 | ± 1.3 | ± 0.4 | ± 0.6 | ± 0.9 | ± 0.4 | |
| Left heart | 243.9 | 276.5 | 227.1 | 273.3 | 290.2 | 263.1 | 235.1 | 224.7 | 237.0 | 326.0 | 257.9 | 260.3 |
| ± 29.8 | ± 30.2 | ± 8.8 | ± 30.3 | ± 47.9 | ± 11.9 | ± 12.9 | ± 38.2 | ± 14.5 | ± 51.8 | ± 24.9 | ± 14.2 | |
| Right heart | 286.9 | 369.3 | 290.9 | 357.2 | 385.1 | 334.0 | 278.7 | 329.2 | 301.5 | 445.7 | 338.4 | 345.6 |
| ± 28.8 | ± 39.5 | ± 15.0 | ± 51.1 | ± 82.5 | ± 19.0 | ± 25.0 | ± 68.9 | ± 22.0 | ± 76.7 | ± 32.1 | ± 23.7 | |
| Left lung | 126.9 | 161.8 | 145.0 | 96.2 | 105.7 | 127.6 | 145.2 | 177.4 | 132.7 | 166.9 | 127.2 | 150.5 |
| ± 21.6 | ± 44.4 | ± 24.7 | ± 27.5 | ± 38.4 | ± 14.0 | ± 25.7 | ± 57.9 | ± 37.2 | ± 47.3 | ± 39.4 | ± 18.3 | |
| Right lung | 142.6 | 106.9 | 119.7 | 91.7 | 100.3 | 111.5 | 132.6 | 226.8 | 164.2 | 160.1 | 147.5 | 167.0 |
| ± 23.9 | ± 18.8 | ± 19.7 | ± 27.1 | ± 39.2 | ± 11.1 | ± 20.0 | ± 57.4 | ± 63.0 | ± 41.4 | ± 37.5 | ± 21.8 | |
| Skeletal Muscle | 18.31 | 20.2 | 17.4 | 12.7 | 14.1 | 16.4 | 14.1 | 17.4 | 16.9 | 20.7 | 16.0 | 17.2 |
| ± 3.4 | ± 5.0 | ± 4.2 | ± 1.5 | ± 3.0 | ± 1.7 | ± 3.3 | ± 2.4 | ± 3.4 | ± 3.8 | ± 2.9 | ± 1.5 | |
| Brain stem | 213.5 | 191.9 | 198.0 | 199.8 | 166.7 | 200.0 | 207.5 | 229.5 | 195.5 | 217.1 | 153.9 | 202.9 |
| ± 20.6 | ± 15.8 | ± 48.0 | ± 29.9 | ± 29.6 | ± 14.1 | ± 12.5 | ± 29.8 | ± 64.6 | ± 34.0 | ± 39.2 | ± 17.7 | |
| Brain cortex | 162.0 | 161.6 | 132.7 | 159.4 | 176.2 | 155.1 | 147.2 | 149.0 | 129.7 | 148.1 | 133.9 | 141.2 |
| ± 17.5 | ± 19.3 | ± 7.8 | ± 18.9 | ± 65.8 | ± 9.8 | ± 7.0 | ± 19.5 | ± 14.6 | ± 11.3 | ± 25.9 | ± 6.7 | |
| Skin | 75.3 | 83.1 | 55.7 | 55.6 | 57.7 | 63.8 | 61.5 | 59.1 | 49.5 | 61.4 | 55.2 | 57.0 |
| ± 6.6 | ± 14.0 | ± 3.7 | ± 7.9 | ± 2.0 | ± 3.7 | ± 7.1 | ± 6.4 | ± 5.0 | ± 6.9 | ± 8.4 | ± 2.9 | |
| Gut | 125.9 | 129.0 | 85.3 | 95.9 | 124.0 | 110.3 | 117.8 | 126.6 | 90.1 | 127.7 | 122.7 | 115.8 |
| ± 10.7 | ± 27.3 | ± 5.1 | ± 10.0 | ± 12.6§ | ± 6.8 | ± 11.5 | ± 19.6 | ± 6.2 | ± 13.6 | ± 12.2 | ± 6.1 | |
| Placenta | 185.1 | 157.2 | 168.6 | 178.7 | 167.7 | 172.5 | 164.1 | 158.4 | 179.7 | 200.9 | 180.6 | 177.1 |
| ± 21.6 | ± 29.9 | ± 7.5 | ± 15.4 | ± 24.8 | ± 8.9 | ± 25.1 | ± 23.1 | ± 10.2 | ± 15.9 | ± 17.9 | ± 8.5 | |
| ECoG state (min hr−1) | ||||||||||||
| HV | 27 | 27 | 26 | 29 | 24 | 27 | 29 | 35 | 28 | 38 | 27 | 35 |
| ± 4 | ± 3 | ± 3 | ± 1 | ± 4 | ± 1 | ± 2 | ± 4 | ± 2 | ± 3 | ± 3 | ± 1* | |
Values are mean ±s.e.m. HV; high voltage ECoG activity. *P < 0.05 versus baseline (all animals), †P < 0.01 versus baseline (all animals), §P < 0.05 versus C2.