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. 2008 Dec 8;587(Pt 3):679–691. doi: 10.1113/jphysiol.2008.161844

Table 3.

Organ weights of rats adjusted for total body weight

Age (days)

7 14 21 28 (on diet) 35 (on diet)
Total body weight (g)
Control 16.7 ± 0.5a 37.0 ± 1.3b 62.0 ± 1.1c 92.1 ± 2.9d 137.4 ± 6.9e
High fibre 92.7 ± 3.8d 145.5 ± 4.5e
High protein 90.0 ± 3.3d 140.7 ± 6.3e
Liver weight (mg g−1)
Control 32.9 ± 2.0a 33.6 ± 4.5ab 39.9 ± 8.5c 43.2 ± 2.04d 47.2 ± 4.0d
High fibre 41.3 ± 2.7d 42.9 ± 3.9d
High protein 46.2 ± 1.8 d 49.9 ± 3.5e
Stomach weight (mg g−1)
Control 7.8 ± 1.0ab 7.4 ± 4.0ab 8.1 ± 5.0ab 8.7 ± 0.5a 7.8 ± 0.8a
High fibre 8.5 ± 0.9a 7.8 ± 1.2a
High protein 9.3 ± 0.6a 7.7 ± 0.7b
Small intestine length (m g−1)
Control 2.2 ± 0.2a 1.4 ± 0.2b 1.1 ± 0.1c 0.9 ± 0.1d 0.7 ± 0.1e
High fibre 1.0 ± 0.1d 0.7 ± 0.1e
High Protein 1.0 ± 0.1d 0.7 ± 0.1e
Small intestine weight (mg g−1)
Control 34.1 ± 1.5a 29.6 ± 4.5b 30.1 ± 7.0bc 33.1 ± 1.8d 30.5 ± 2.3e
High fibre 35.4 ± 1.0d 33.2 ± 2.5e
High protein 34.2 ± 1.3d 34.3 ± 2.7 d
Colon length (mm g−1)
Control 2.55 ± 0.01a 1.65 ± 0.01b 1.26 ± 0.01c 1.12 ± 0.01c,x 0.86 ± 0.01d,x
High fibre 1.30 ± 0.01c,y 1.02 ± 0.01d,y
High protein 1.03 ± 0.01c,x 0.89 ± 0.01d,x
Colon weight (mg g−1)
Control 3.0 ± 1.0a 3.8 ± 4.0a 4.4 ± 1.1ab 5.2 ± 0.3c,x 5.1 ± 0.6c,x
High fibre 6.3 ± 0.3c,y 6.4 ± 0.7c,y
High protein 5.5 ± 0.4c,x 4.9 ± 0.8c,x

Values are means ±s.e.m. with an n= 20 males (M) and 16 females (F) on day 7; n= 16 (M) and 19 (F) on day 14; n= 16 (M) and 17 (F) on day 21; n= 6 (M) and 6 (F) per diet group on days 28 and 35 each. Superscripts ‘a’ to ‘e’ represent significant differences (P < 0.05) between ages within a row. Superscripts ‘x’ and ‘y’ represent a significant difference (P < 0.05) between diet groups for both males and females within an age category. Values with different letters are significantly different from each other. ‡Significant difference in one sex only; in males only on d28 between the high protein diet versus control and fibre for liver weight (P < 0.05); in females only on d35 between the high protein diet compared to control (P= 0.01) and high fibre for liver weight (P= 0.01); and in males only on d35 between high protein versus control (P < 0.05) only for small intestine weight.