Table 1.
Activity of INH1, INH2 and their analogues
| Compound | Structure | IC50 (μM) | |||
|---|---|---|---|---|---|
| MB231 | MB468 | HeL a | K562 | ||
| INH1 |
|
8.6 | 10.5 | 8.8 | 11.7 |
| INH2 |
|
9.7 | 11.2 | 13.6 | 9.5 |
| 3 |
|
>40 | >40 | >40 | >40 |
| 4 |
|
>40 | >40 | >40 | >40 |
| 5 |
|
23.4 | >40 | >40 | >40 |
| 6 |
|
1.7 | 2.1 | 2.4 | 2.5 |
| 7 |
|
>40 | >40 | >40 | >40 |
| 8 |
|
5.9 | 4.1 | 10.6 | 7.5 |
| 9 |
|
7.5 | 6.2 | 14.5 | 13.3 |
| 10 |
|
4.1 | 2.3 | 5.2 | 4.9 |
| 11 |
|
4.1 | 5.5 | 5.8 | 8.2 |
| 12 |
|
3.2 | 3.0 | 3.6 | 3.9 |
| 13 |
|
1.1 | 3.4 | 1.6 | 1.2 |
| 14 |
|
>25 | >25 | >25 | >25 |
| 15 |
|
3.2 | 4.7 | 5.7 | 5.9 |
| 16 |
|
>25 | >25 | >25 | >25 |
| 17 |
|
6.8 | 10.7 | 11.2 | 10.1 |
| 18 |
|
2.9 | 6.2 | 7.4 | 10.1 |
| 19 |
|
4.7 | 11.8 | 11.2 | 14.5 |
| 20 |
|
5.8 | 4.0 | 4.7 | 4.2 |
| 21 |
|
1.6 | 4.2 | 2.5 | 3.8 |
| 22 |
|
>40 | >40 | >40 | >40 |
| 23 |
|
>40 | >40 | >40 | >40 |
| 24 |
|
13.5 | 16.0 | 20.2 | 14.8 |
| 25 |
|
11.6 | 10.8 | 14.1 | 9.2 |
| 26 |
|
10.6 | 18.7 | >40 | 15.5 |
| 27 |
|
22.1 | 21.0 | 22.0 | 23.7 |
| 30 |
|
15.8 | 20.2 | 22.2 | 20.2 |
| 31 |
|
>40 | >40 | >40 | >40 |
| 32 |
|
11.8 | 14.4 | 14.4 | 14.8 |
| 33 |
|
22.5 | 21.3 | >40 | >40 |
| 36 |
|
7.2 | 10.7 | 10.6 | 7.3 |
| 37 |
|
11.8 | >40 | 13.1 | 11.9 |
| 39 |
|
14.4 | 16.0 | 18.6 | 19.2 |
| 40 |
|
21.1 | 19.6 | 18.6 | 22.9 |