FIGURE 5.

FGF15 adenovirus effects on CYP7A1 and PEPCK gene expression in WT and l-FoxO1 mice. Wild type or l-FoxO1 littermate control floxed mice were inoculated with the specified adenovirus constructs and fed a chow diet or fasted as described under “Experimental Procedures.” Total RNA was isolated and analyzed for CYP7A1 (left) or PEPCK (right) gene expression as noted. The data are plotted as relative expression compared with ad libitum-fed control samples (set at 1.0). Where pairwise comparisons provide p < 0.01, samples are labeled with a different symbol. KO, knock out.