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Rate of product formation by cyt P450 2B4 under single turnover conditions in the presence of wild-type and ΔTGEE CYPOR
| Substrate | Reductase | k (s–1) | Yielda |
|---|---|---|---|
| Benzphetamine | Wild type | 0.15 ± 0.05 | 0.7 |
| ΔTGEE | 0.1 ± 0.014 | 0.52 | |
| Cyclohexane | Wild type | 2.5 ± 0.05 | 0.21 |
| ΔTGEE | 3.3 ± 0.3 |
Expressed in units of nmol of product, norbenzphetamine or cyclohexanol, per nmol of cyt P450. The reactions were conducted as described under “Experimental Procedures”
