FIGURE 5.

GLEPP1 inhibitors prevent thioglycolate-induced peritoneal recruitment of leukocytes. Compound 1 (A), Compound 2 (B), or vehicle (control) were orally administered 15 min prior to and 24 h after intraperitoneal injection of thioglycolate in C3H mice. Peritoneal leukocytes were counted 48 h later. The percentage inhibition was calculated against control (vehicle-treated) animals and corrected for background (from animals not injected with thioglycolate; see supplemental material for calculation of raw data). Statistics were calculated using analysis of variance and Dunnett's test, and p value cut-offs are indicated. Dexamethasone was used as a reference compound for inducing inhibition.