TABLE 1.
Selectivity of inhibitors among protein-tyrosine phosphatases Shown are Compound 1 and 2 IC50 values (nm) for 10 PTPs, representing different PTP family subclasses. S.D. values represent at least three independent experiments.
| PTP | Compound 1 | Compound 2 |
|---|---|---|
| nm | nm | |
| Glepp1 | 123 ± 35 | 340 ± 407 |
| PTP1B | 589 ± 88 | 611 ± 238 |
| Pac1 | 5,630 ± 1,520 | 7,500 ± 1,252 |
| PTP-β | 8,050 ± 1,399 | 5,866 ± 2,804 |
| PTPH1 | 5,438 ± 2,417 | 3,240 ± 2,894 |
| PTP-μ | 5,610 ± 914 | 20,903 ± 2,975 |
| SHP-1 | 673 ± 188 | 1,008 ± 499 |
| SHP-2 | 393 ± 81 | 652 ± 506 |
| TC-PTP | 553 ± 419 | 973 ± 460 |
| VHR | 650 ± 101 | 703 ± 286 |