Bone histomorphometric parameters of 10-week-old male F2 transgenic and
age-matched male WT littermates at the metaphysis of L4 vertebrae. TRACP+
cells were stained in pink. Measurements were performed at the bone
site 350 μm away from the edge. Top, a representative longitudinal
section of a WT littermate and that of a transgenic mouse. Scale
bars, 300 μm. The bottom summarizes the quantitative results
(mean ± S.E. of 13 transgenic mice and nine WT mice). Tb.PM,
trabecular perimeter; NOC/BS.Pm, number of TRACP+ osteoclasts per
bone surface length; T.Ar, total tissue area; Tb.Ar,
trabecular bone area per total tissue area; Tb.N, trabecular number;
Tb.Sp, trabecular separation; Tb.Th, trabecular
thickness.