FIGURE 7.

Comparison of μ-CT bone parameters of young adult OVX transgenic with those of young adult WT OVX littermates. Groups of five each of 8-week-old female PTP-oc transgenic mice and age-matched WT littermates were subjected to OVX or sham operation. Four weeks after the operation (i.e. at 12 weeks of age), all mice were sacrificed, and the bone parameters of right femurs were determined by μ-CT as described under “Experimental Procedures.” There were no statistically significant differences (N.S.) in any of the test parameters between the sham-operated transgenic and WT mice. To more clearly show the differences in response to OVX, the results were shown as a percentage of the means of each corresponding sham-operated controls. A-E, trabecular bone parameters measured at the secondary spongiosa. F, the cortical bone volume per tissue volume parameter determined at the midshaft. Statistical significance was determined by two-tailed Student'st test. Trab.., trabecular; Tb.N, trabecular number; Tb.Sp, trabecular separation; Tb.Th, trabecular thickness; Cort., cortical.