TABLE 4.

Comparison of bone phenotype of 8-week-old female F2 transgenic mice of transgenic line 1 (TG) with corresponding age- and sex-matched wild-type littermates (WT) (mean ± S.E.)

	F2 mice		Backcrossed for six generations
	WT (n = 11)	TG (n = 8)	WT (n = 25)	TG (n = 25)
Bone length (mm)	13.5 ± 0.2	13.9 ± 0.1	13.5 ± 0.1	13.6 ± 0.1
Bone volume (mm3)	2.07 ± 0.08	2.16 ± 0.06	2.08 ± 0.05	2.07 ± 0.05
Total bone area (mm2)	1.54 ± 0.03	1.50 ± 0.03	1.55 ± 0.03	1.51 ± 0.02
Cortical bone area (mm2)	0.76 ± 0.06	0.72 ± 0.09	0.89 ± 0.10	0.87 ± 0.02
Cortical thickness (mm)	0.26 ± 0.01	0.25 ± 0.01	0.29 ± 0.02	0.25 ± 0.00
Periosteal circumference (mm)	4.58 ± 0.03	4.48 ± 0.06	4.37 ± 0.04	4.36 ± 0.03
Endosteal circumference (mm)	3.27 ± 0.06	3.33 ± 0.04	3.19 ± 0.04	3.15 ± 0.04
Total BMC (mg)	2.23 ± 0.10	1.95 ± 0.13	2.18 ± 0.06	2.05 ± 0.06
Cortical BMC (mg)	1.35 ± 0.06	1.31 ± 0.04	1.34 ± 0.04	1.33 ± 0.03
Trabecular BMC (mg)	0.68 ± 0.08	0.65 ± 0.13	0.66 ± 0.05	0.46 ± 0.03a
Total BMD (mg/mm3)	701.6 ± 11.8	658.1 ± 18.4	588.7 ± 11.6	558.0 ± 9.0b
Cortical BMD (mg/mm3)	993.4 ± 53.2	1063.0 ± 14.4	963.1 ± 44.5	1014.7 ± 33.0
Trabecular BMD (mg/mm3)	320.8 ± 26.2	289.6 ± 43.4	314.9 ± 15.9	246.7 ± 9.2c

^ap < 0.005 versus corresponding WT littermates by two-tailed Student's t test.

^bp < 0.05 versus corresponding WT littermates by two-tailed Student's t test.

^cp < 0.001 versus corresponding WT littermates by two-tailed Student's t test.