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. 2009 Feb 25;29(8):2414–2427. doi: 10.1523/JNEUROSCI.5687-08.2009

Figure 6.

Figure 6.

D2 receptor responses in 12-month-old YAC128 mice. A, In 12-month-old WTs, both quinpirole (Quin) and amphetamine (Amph) inhibited FM1-43 release. Sulpiride (Sulp) reversed the effect of Amph. B, Distribution of mean t1/2 of release for destaining curves shown in A. n = 258, 56, 157, and 127 puncta for vehicle (Veh), Quin, Amph, and Amph+Sulp, respectively. ***p < 0.001 compared with Veh, Mann–Whitney test. C, Individual terminal halftimes of release from averaged puncta shown in A. D, In slices from 12-month-old YAC128 mice, both Quin and Amph inhibited FM1-43 release. Sulp reversed the modulating effect of Amph. E, Distribution of mean t1/2 of release for destaining curves shown in D. n = 139, 133, 153, and 96 puncta for Veh, Quin, Amph, and Amph+Sulp, respectively. **p < 0.01 compared with Veh, Mann–Whitney test. F, Individual terminal halftimes of release from averaged puncta shown in D. G, Percentage change in average corticostriatal terminal halftimes after Amph. n = 4 mice per condition. *p < 0.05, ANOVA. H, Percentage change in average corticostriatal terminal halftimes after Quin. n = 4 mice per condition. *p < 0.05, ANOVA. Curves for G and H were fit with a Hill equation.