Table 1.

Leptin-Receptor Mutations in Subjects with Severe Early-Onset Obesity.

Mutation	Family No.	No. of Affected Subjects	Race or Ethnic Group*
Homozygous frame-shift
4-bp deletion in codon 22	1	3 (1 deceased)	Bangladeshi
11-bp deletion in codon 70	2	2	Turkish
66-bp deletion in codon 514	3	1 (deceased)	Iranian
Homozygous nonsense
W31X	4	3	Southern European
Homozygous missense
A409E	5	1	Turkish
W664R	6	1	Norwegian
H684P	7	1	White (United Kingdom)
Compound heterozygous
1-bp deletion in codon 15 and R612H	8	1	White (United Kingdom)

^*Race or ethnic group was assigned by the physician.