Differences in baseline 5-HTT BPP between controls and subjects with major depression who remit or do not remit by one-year follow-up. Non-remitters have lower 5-HTT BPP than healthy controls in the linear mixed-effects model, comparing all regions simultaneously (p=.005). Reported levels of significance are for post-hoc tests of group-by-region effects. Regions of interest: anterior cingulate (ACN), amygdala (AMY), dorsal putamen (PUT), hippocampus (HIP), midbrain (MID), thalamus (THA). Error bars represent one standard deviation from mean values. * = p<.05, ** = p<.01, *** = p<.001.