. Author manuscript; available in PMC: 2010 Feb 1.

Published in final edited form as: Bioorg Med Chem. 2008 Dec 24;17(3):1222–1231. doi: 10.1016/j.bmc.2008.12.025

Table 1.

In vitro σ receptor binding and log P data for the phenylcarbamate analogs.

Compounds	K_i (nM)		σ₁/σ₂	Log P
Compounds	σ₁	σ₂	σ₁/σ₂	Log P
11a	2,003.3 ± 215.7	143.3 ± 4.2	14	2.85
11b	1,256.8 ± 87.9	85.9 ± 3.2	15	2.86
11c	1,563.3 ± 415.9	521.6 ± 15.1	3	2.94
11d	2,346.7 ± 340.7	183.9 ± 13.0	13	2.70
11e	2,510.0 ± 477.6	571.5 ± 142.8	4	3.21
11f	2,023.3 ± 344.0	8,192.1 ± 25.9	11	3.92
11g	323.3 ± 40.8	40.7 ± 4.4	8	3.3
WC-59	1,710.5 ± 84.0	0.82 ± 0.13	2,087	3.68
WC-26	1,436.5 ± 166.1	2.58 ± 0.59	557	3.02
11h	447.1 ± 66.9	125.8 ± 27.2	4	3.22
11i	2,633.3 ± 672.9	275.8 ± 78.2	10	3.69
11j	1,870.0 ± 338.3	195.2 ± 32.0	10	3.36
Haloperidol	1.45 ± 0.33	24.2 ± 3.0	0.06	3.36