Table 1.
Rescue of neuro-vascular phenotypes with Birc5 mRNAs
| Buffer or Specific mRNA Co-injected | ||||||
| Phenotype | Buffer | Birc5a mRNA(n = 162) | Birc5b mRNA(n = 180) | Birc5a mRNA(n = 134) | Birc5b mRNA(n = 173) | |
| Birc5a kd | Neuro | 61% (of 276) |
8% | 21% | ||
| Vascular | 40% (of 276) |
10% | 22% | |||
| Birc5b kd | Neuro | 26% (of 263) |
5% | 6% | ||
| Vascular | 38% (of 263) |
4% | 8% | |||
Birc5 morpholinos were injected into Tg(Fli:eGFP) zebrafish embryos simultaneously with injections of specific mRNAs as shown, and phenotypic analyses were performed at 2 dpf. The incidence of neural or vascular abnormalities is illustrated.