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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Biochim Biophys Acta. 2009 Jan 22;1795(2):162–172. doi: 10.1016/j.bbcan.2009.01.001

FIGURE 4. HIF-1α: schematic outline of the domain structure, function of individual domains, and sites hydroxylated by PHDs and FIH-1.

FIGURE 4

bHLH, basic loop-helix-loop; CAD, C-terminal activation domain; FIH-1, factor inhibiting HIF 1; NAD, N-terminal activation domain; NLS, nuclear localization signal; ODDD, O2–dependent degradation domain; PAS, PER-ARNT-SIM; PHDs, prolyl hydroxylases.