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. Author manuscript; available in PMC: 2010 Mar 17.
Published in final edited form as: Neuroscience. 2009 Mar 17;159(2):501–513. doi: 10.1016/j.neuroscience.2009.01.021

Figure 5. HFS-LTD is detected in ASOTg striatum.

Figure 5

A. HFS induced significant LTD in ASOTg (* P =0.004) but not in WT striatum (P = 0.13). Responses shown are averaged synaptic field potentials recorded pre-HFS (5 min) and post-HFS (25-30 min). B. Paired-pulse facilitation increases in WT and ASOTg slices after HFS induction of LTD. A 2nd field potential response was recorded at a 50 msec interstimulus interval to obtain a PPR before and after HFS induction. The PPR remained above 1.0 pre-HFS and increased significantly post-HFS, indicative of alterations in paired-pulse facilitation when ASOTg LTD was induced (*P = 0.001).