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. 1999 Mar 2;96(5):1875–1880. doi: 10.1073/pnas.96.5.1875

Figure 5.

Figure 5

Three-dimensional model for four p53DBD subunits bound to bent DNA. The H2 helices are involved in direct DNA recognition in the major groove (24). The H1–H1 interactions are operative in causing DNA bending and twisting (26, 29). The broken lines indicate that in the wt p53 tetramer bound to DNA, the N termini are located on the external side of the DNA loop, whereas the C termini fragments are on the internal side (the tetramerization and basic domains are not shown). Small arrows denote putative interactions between the proline-rich N fragments and the p53 core domains.