Table 2.
Features of NASH patients according to high and normal aminotransferase levels n (%)
|
NASH cases (n = 23) |
P | ||
| Normal aminotransferase levels (n = 7) | Elevated aminotransferase levels (n = 16) | ||
| Age (yr) | 52.8 ± 5.04 | 50.44 ± 5.12 | > 0.05 |
| Gender (male/female) | 1/6 (14.2/85.8) | 6/10 (37.5/62.5) | > 0.05 |
| Hepatomegaly | 2 (28.5) | 5 (31.2) | > 0.05 |
| BMI (kg/m2) | |||
| Normal weight | - | - | |
| Overweight | - | - | |
| Obese | 6 (85.7) | 14 (87.5) | > 0.05 |
| Morbid obese | 1 (14.3) | 2 (12.5) | > 0.05 |
| Waist/hip ratio | 5 (71.4) | 12 (75.0) | > 0.05 |
| Systolic blood pressure (mmHg)1 | 130.0 (110-150) | 120 (110-180) | > 0.05 |
| Diastolic blood pressure (mmHg)1 | 80 (60-90) | 70 (60-120) | > 0.05 |
| Hypertension | 3 (42.9) | 7 (43.8) | > 0.05 |
| HDL-Cholesterol (mg/dL) | 43.86 ± 8.97 | 44.19 ± 4.07 | > 0.05 |
| Low-HDL level | 4 (57.1) | 9 (56.3) | > 0.05 |
| Triglycerides (mg/dL) | 183.57 ± 95.82 | 130.44 ± 59.46 | > 0.05 |
| Hypertriglyceridemia | 5 (71.4) | 5 (31.3) | > 0.05 |
| Fasting glucose (mg/dL)1 | 101 (73-164) | 102.83 (87-195) | > 0.05 |
| Diabetes | 2 (28.6) | 4 (25.0) | > 0.05 |
| Impaired glucose tolerance | 3 (42.9) | 6 (37.5) | > 0.05 |
| Fasting insulin (μU/mL) | 11.8 | 13.96 | > 0.05 |
| Insulin resistance-HOMA-IR | 1 (14.3) | 9 (56.3) | > 0.05 |
| AST (IU/L)1 | 18 (14-29) | 46 (33-92) | < 0.05 |
| ALT (IU/L)1 | 21 (15-39) | 77 (32-158) | < 0.05 |
| GGT (IU/L)1 | 21 (15-33) | 40 (16-119) | < 0.05 |
| ALP (IU/L)1 | 96 (52-111) | 78.5 (55-152) | > 0.05 |
| Metabolic syndrome | 6 (85.7) | 12 (75.0) | > 0.05 |
1
Data expressed as median (minimum-maximum); BMI: Body mass index; HDL: High-density lipoprotein; ALP: Alkaline phosphatase; GGT: Gamma glutamyl transpeptidase. There was no difference between the features of NASH patients with high and normal aminotransferase levels.