Table 3.
Features of NASH patients with high and normal aminotransferase levels according to the presence of metabolic syndrome n (%)
|
NASH cases (n = 23) |
P | ||
| With metabolic syndrome (n = 18) | Without metabolic syndrome (n = 5) | ||
| Average age (yr) | 52.7 ± 4.34 | 45.4 ± 3.20 | < 0.05 |
| Gender (male/female) | 3/15 (16.7/83.3) | 4/1 (80.0/20.0) | < 0.05 |
| Hepatomegaly | 5 (29.4) | 2 (50) | > 0.05 |
| BMI (kg/m2) | |||
| Normal weight | - | - | |
| Overweight | - | - | |
| Obese | 15 (83.3) | 5 (100) | > 0.05 |
| Morbid obese | 3 (16.7) | 0 (0) | > 0.05 |
| Waist/hip ratio | 13/(72.2) | 4 (80.0) | > 0.05 |
| Hypertension | 10 (55.6) | 0 (0) | < 0.05 |
| Low HDL level | 13 (72.2) | 0 (0) | < 0.05 |
| Hypertriglyceridemia | 10 (55.6) | 0 (0) | < 0.05 |
| Diabetes | 5 (27.8) | 1 (20.0) | > 0.05 |
| Impaired glucose tolerance | 8 (44.4) | 1 (20.0) | > 0.05 |
| Insulin resistance-HOMA-IR | 6 (75) | 4 (80.0) | > 0.05 |
| AST (IU/L) | 38. 06 ± 16.63 | 53.60 ± 27.04 | > 0.05 |
| ALT (IU/L) | 57.39 ± 32.127 | 84.8 ± 49. 37 | > 0.05 |
| AST/ALT > 1 | 3 (16.6) | 1 (20.0) | > 0.05 |
| GGT (IU/L)1 | 29.5 (15-83) | 33 (16-119) | > 0.05 |
| ALP (IU/L) | 83.44 ± 18.19 | 98.20 ± 38.78 | > 0.05 |
1
Data expressed as median (minimum-maximum); BMI: Body mass index; HDL: High-density lipoprotein; ALP: Alkaline phosphatase; GGT: Gamma glutamyl transpeptidase. There were significant differences between NASH cases with or without metabolic syndrome according to average age, gender and the presence of hypertension, low-HDL level and hypertriglyceridemia.