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. Author manuscript; available in PMC: 2010 Jan 29.
Published in final edited form as: Neuron. 2009 Jan 29;61(2):187–202. doi: 10.1016/j.neuron.2008.11.026

Figure 3. Effect of time between events on pattern separation and pattern integration.

Figure 3

(A) Schematic showing the pattern separation experiment extended over time. The model continued to grow with maturation, neurogenesis and cell death between testing sessions, at which time the response of the model was measured at different environments and spatial locations. (B) Effect of time between events on pattern separation of inputs that are 80% (top), 50% (middle), and 10% (bottom) similar. Note how DG similarities between events separated in time are lower than those tested on the same day. Both the decrease in similarity over time and the interaction between time and NG/No NG groups were significant for each of the input similarity groups (p<0.01). (C) Cartoon schematic of temporal separation. Two similar events, when separated by time, will activate distinct mature DG neurons, but also a different population of immature neurons, increasing the separation of the two events.