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. Author manuscript; available in PMC: 2009 Apr 20.
Published in final edited form as: Hepatology. 2009 Apr;49(4):1297–1307. doi: 10.1002/hep.22753

Figure 1.

Figure 1

Mouse HSC express CtsB and CtsD. (A) Time-course of CtsB, CtsD, and α-SMA protein expression by western blot. (B) CtsB and CtsD activity. (C) CtsB and CtsD present in the extracellular media (EM) differ from the intracellular form (CL). Western blot displaying two representative experiments (Experiment #1: lane 1-2; experiment #2: lane 3-4). (D-F) Confocal imaging of 7 day-old HSC displaying CtsB, CtsD, with a lysosomal marker (LAMP2b) (D), among themselves (E), and with early (Rab5A) or late (Rab11) endosome markers (F). Data are mean±SD, n=4 and *p≤ 0.05 vs. day 2 HSC. Scale bar 10μm (D-F).