Table 1. Electrical properties of young and mature neurons.
| young | mature | p | |
| INTRINSIC PROPERTIES | |||
| Rin (MΩ) | 519±30 (68) | 224±7 (89) | <0.0001 |
| Cm (pF) | 30.6±1.0 (68) | 56.9±2.1 (89) | <0.0001 e |
| Tau (ms) a | 32.5±2.4 (25) | 34.0±2.0 (25) | 0.634 |
| Vresting (mV) | −75.6±0.5 (42) | −80.6±0.5 (60) | <0.0001 |
| Ithreshold (pA) | 29.0±1.7 (42) | 58.8±2.5 (60) | <0.0001 e |
| Vthreshold (mV) | −42.8±0.9 (38) | −38.4±0.9 (55) | 0.0011 |
| AHP (mV) | −57.7±0.5 (23) | −59.8±0.4 (23) | 0.0024 e |
| spike amplitude (mV) | 113.8±0.8 (23) | 118.8±0.4 (23) | <0.0001 |
| spike slope (V/s) | 266±8 (23) | 309±6 (23) | 0.0002 |
| Max gNa+ (nS) b | 307±20 (26) | 423±6 (29) | <0.0001 |
| Max gK+ (nS) c | 189±13 (26) | 288±16 (29) | <0.0001 |
| gKir (nS) d | 1.73±0.32 (16) | 5.18±0.34 (20) | <0.0001 |
| SYNAPTIC PROPERTIES | |||
| EPSC Rise (ms) | 3.64±0.13 (40) | 3.37±0.13 (40) | 0.16 |
| EPSC Decay (ms) | 21.8±0.9 (40) | 25.1±0.9 (40) | 0.009 |
| EPSP Rise (ms) | 7.01±0.18 (42) | 5.83±0.18 (39) | <0.0001 |
| EPSP Decay (ms) | 34.0±1.8 (43) | 37.3±2.0 (42) | 0.22 |
a
Tau measured by fitting a single exponential equation to the membrane potential response to a current pulse (10 pA)
b
gNa+ measured at Vh = −20 mV
c
gK+ measured at steady state at Vh = 70 mV
d
gKir+ measured as described in Methods
e
Welch's correction for differences in variances was applied.
Mean±SEM are shown, with cell numbers in parentheses. Statistical analyses were performed by two-tailed t-tests.