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. 2009 May 1;5(5):e1000411. doi: 10.1371/journal.ppat.1000411

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Arrecubieta et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A model illustrating the potential role of SdrF in S. epidermidis colonization and infection of a transcutaneous driveline (DL). SdrF mediates the initial attachment of S. epidermidis found colonizing the skin to Dacron fibers. Bacteria cross the transcutaneous site (TC) and adhere via the SdrF B domain to collagen fibers (Cn) deposited on the internal DL surface, leading to subsequent biofilm (BF) formation, colonization, and potential infection.