Fig. 3. Transduction of striated muscle with an AAV2/8 vector.
(A) Periodic acid/Schiff staining following intravenous AAV-MHCK7hGAApA vector administration to GAA-KO mice. Control mice were sham-treated, age-matched GAA-KO mice (PBS). Original magnification: 200. (B) Alkaline phosphatase staining following intravenous AAV-αMHCKChAP administration to GAA-KO mice. Sham-treated GAA-KO mice stained negatively for alkaline phosphatase in striated muscle (not shown; see ref. 14, Figs 3 and 5). Original magnification: 400.