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. 2008 Dec 2;17(2):245–252. doi: 10.1038/mt.2008.259

Figure 3.

Figure 3

Correction of anemia and compensatory splenic extramedullary hematopoiesis in mice transplanted with γ-globin lentiviral vector-transduced cells. (a) Hemoglobin (Hb) levels of individual mice transplanted with mock-transduced cells or cells transduced with the indicated vectors. The mean Hb level in V5m3 mice was higher than that of V5 mice (P = 0.0032), as well as those of the green fluorescent protein (GFP) and mock groups (P < 0.0001). The mean Hb level of the V5 mice was also statistically higher than those of the GFP and mock groups (P < 0.0001). Data were obtained 4–5 months post-transplantation. (b) red blood cell (RBC) counts of mice transplanted with the indicated mock- or vector-transduced cells. The V5m3 mean RBC count was higher than that of the V5 group (P = 0.05). Both the V5 and V5m3 had mean RBC counts were higher than the mock and GFP groups (P < 0.0001). Data were obtained 4–5 months post-transplantation. (c) Spleen weights of the indicated groups of transplanted mice. Mean values for each group are represented by the horizontal line and the P value for the comparison between V5 and V5m3 is indicated. Mean values for V5 and V5m3 were significantly different from that of the mock group (P < 0.0001). Data were obtained 4–5 months post-transplantation. (d) Wright-Giemsa-stained peripheral blood smears from representative mice transplanted with mock-transduced or γ-globin vector-transduced cells as indicated. Data were obtained 4–5 months post-transplantation.