Figure 6.

Correction of splenic, renal, and hepatic sickle cell-related pathologic abnormalities in mice receiving transplants of γ-globin vector-transduced hematopoietic stem cells. (a) Representative hematoxylin and eosin (H&E)-stained sections of renal tubular epithelium (×400) from mock and V5m3mice. (b) Examples of renal glomeruli from mock and V5m3 mice (×400). (c) Representative spleen sections from mock and V5m3 mice stained with H&E at ×100 magnification. (d) Representative sections of liver from mock and V5m3 mice (×400). (e) Liver sections from the indicated mice stained for iron content with Prussian blue (×200).