(A) Ratio of surrounding organ HU to HU of tumor adjacent to liver, spleen, and stomach with different doses of contrast. In the pre-mice, ratios are close to 1 but, in general, increase with increasing doses of contrast. Bone to tumor HU ratio changes minimally. *P < .05 of ratio compared with the ratio at the previous dose within the same organ to tumor. (B) Comparison of ratios of HU of spleen, liver, bowel, and peritoneum to tumor adjacent to the liver, spleen, and stomach in mice administered oral, IP, and RES-IV contrasts at the highest dose, with immediate and delayed imaging of mice administered oral, IP, and IE-IV contrasts. Ratio of HU of spleen to tumor is significantly higher with the RES-IV regimen compared with both immediate and delayed imaging with the IE-IV regimen. *P < .05 comparing ratio to pre-mice. +P < .05 comparing ratio for RES-IV regimen to IE-IV regimen.