Fig. 7.

FAAH inhibitors dose-dependently reduce compound 48/80 scratching without hypomotility. A, dose-response of FAAH inhibitors in attenuating scratching response to compound 48/80. The irreversible FAAH inhibitor URB597 (0.3, 1, 3, and 10 mg/kg i.p.) was given 1 h before compound 48/80, shown as closed black squares (▪) with solid black line. The reversible FAAH inhibitor OL-135 (1, 3, 10, and 30 mg/kg i.p.) was also given 1 h before compound 48/80, shown as open gray circles (○) with dashed gray line. Inset, structure and descriptions of both FAAH inhibitors. B, dose response of behavioral inactivity of the FAAH inhibitors in response to compound 48/80. ⋆, p < 0.05; ⋆⋆, p < 0.01 versus vehicle (Dunnett's post hoc test). n = 8 mice/dose.