TABLE 1.

EC₅₀ values in nanomolar ± S.E.M. for monoamine releasers to release dopamine, norepinephrine, and serotonin The ratios of 5-hydroxytryptamine (5HT) EC₅₀/dopamine (DA) EC₅₀ and norepinephrine (NE) EC₅₀/DA EC₅₀ are also shown. Higher ratios imply greater selectivity for releasing dopamine. For all compounds, potency to release NE was higher than potency to release DA.

Drug	DA	NE	5HT	5HT/DA	NE/DA
Benzylpiperazinea	307 ± 19	62.2 ± 6.5	6051 ± 835	20	0.20
(+)Phenmetrazineb	87.4 ± 7.8	37.5 ± 4.3	3246 ± 263	37	0.43
4-Benzylpiperidinea	109 ± 9	41.4 ± 3.4	5246 ± 977	48	0.38

^aUnpublished data. EC₅₀ values determined using methods identical to those reported by Rothman et al. (2002b)

^bRothman et al. (2002b)