Fig. 4.

¹³CO₂ breath patterns (mean ± S.E.) versus time in healthy volunteers with CYP2C19^*1/^*1 (EMs), CYP2C19^*1/^*2 or CYP2C19^*1/^*3 (IMs), and CYP2C19^*2/^*2 (PMs) genotypes after oral administration of a solution consisting of 100 mg of [¹³C]pantoprazole sodium-sesquihydrate and 2.1 g of sodium bicarbonate. Breath samples were collected at baseline (before drug administration) and up to 120 min after pantoprazole dosing. The amounts of ¹³CO₂ in breath (expressed as DOB) were multiplied by body weight versus time (A), body weight uncorrected DOB versus time (B), and cumulative PDR (C). Breath test indices calculated from the data in B and C are presented in Table 2.