TABLE 4.
Parameters | EM (n = 3) | IM (n = 3) | PM (n = 3) | p Valuea |
---|---|---|---|---|
Tmax (h) | 0.5 | 0.5 | 0.5 | |
Half-life (h) | 0.88 ± 0.14* | 1.60 ± 0.61 | 4.23 ± 0.57 | 0.0439 |
Cmax (μg/ml) | 4.06 ± 1.16 | 4.39 ± 0.61 | 4.29 ± 1.88 | 0.88 |
AUC0—120 (h/μg/ml) | 4.99 ± 1.08* | 9.96 ± 3.43 | 21.19 ± 4.25 | 0.0439 |
AUC0—∞ (h/μg/ml) | 5.09 ± 1.08* | 10.35 ± 3.69 | 24.94 ± 4.08 | 0.0439 |
Vz/F (liters) | 26.20 ± 8.35 | 22.20 ± 1.48 | 25.10 ± 7.35 | 0.88 |
Cl (ml/h/kg) | 326.9 ± 97.00* | 159.30 ± 52.00 | 67.78 ± 7.60 | 0.0439 |
AUC, area under the concentration versus time curve, 0 to 120 min or 0 to infinity; Vz/F, apparent volume of distribution; Cl, apparent oral clearance corrected for body weight
p < 0.05, PM versus EM
Comparison between the three genotypes was compared by Kruskal-Wallis statistic with post-hoc analysis using Dunn's Multiple Comparison Test