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. 2009 Jan 23;329(1):26–37. doi: 10.1124/jpet.108.148536

Fig. 2.

Fig. 2.

Partition ratio determination for the inactivation of CYP2B6 by RU486. The percentage of CYP2B6 catalytic activity remaining was determined as a function of the molar ratio of RU486 to P450. Samples were incubated with various concentrations of RU486 for 1 h in the presence of NADPH until the inactivation reaction was essentially complete. The partition ratio was estimated from the intercept of the linear regression line from the lower ratios of RU486 to CYP2B6 and the straight line obtained from higher ratios of RU486 to CYP2B6.