Fig. 7.

Schematic model of the predicted transcription factor binding sites and location of SNPs in the OCTN1 and OCTN2 promoters. Transcription binding factors of OCTN1 promoter RUNX1 and Sp1 have been reported previously by Maeda et al. (2007). There were no SNPs in these binding sites of the OCTN1 promoter. The -207G in the OCTN2 promoter has been reported previously to create a binding site for a heat shock element (HSE) (Peltekova et al., 2004). A change from C to G at position -207 creates the HSE binding site, resulting in an increase in transcriptional activity.