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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Curr Opin Pharmacol. 2009 Jan 20;9(1):24–30. doi: 10.1016/j.coph.2008.12.006

Fig. 1.

Fig. 1

Simplified cortical circuitry that depicts the action of Allo on GABAA receptors (GR) expressed on the cell body, dendrites, or axon hillocks of a pyramidal neuron.

Allo is synthesized in pyramidal neurons by the action of 5α-R-type I and 3α-HSD.

Allo diffuses (indicated by Inline graphic) to cell membranes and facilitates the action of GABA at synaptic and extrasynaptic GABAA receptors.

Inline graphic, denotes Allo biosynthesis downregulation in pyramidal neurons of socially isolated mice.

Inline graphic, denotes a decrease of Allo levels reaching synaptic or extrasynaptic GABAA receptors located on pyramidal neurons in socially isolated mice.

GRαxβxInline graphic, extrasynaptic GABAA receptors that express δ subunits.