Table 1.

Tibial BMD in 3-mo-old mCSF1 transgenic, sCSF1 transgenic, and m/sCSF1 double transgenic mice

Genotype	No. of Mice	BMD, g/cm3	Mean %Reduction Compared with Controls	P Value*
sCSF1	13	386±8.9	14	< 0.01
m/sCSF1	33	378±10.7	16	< 0.01
Wild type	57	450±12.4

Data are means ± SE. sCSF1, soluble transgene for colony-stimulating factor-1; m/sCSF1, membrane-bound and soluble isoform double transgene for colony-stimulating factor-1, respectively; BMD, bone mineral density.

^*Compared to wild-type controls.