Table 2.
Histomorphometric data in 8- to 12-wk-old male and female transgenic and wild-type animals
| n | BV/TV | BS/BV | ObS/BS | OcS/BS | NOb/TAR | NOc/TAR | NOc/Bpm | |
|---|---|---|---|---|---|---|---|---|
| sCSF1 mice | ||||||||
| Male | 10 | 19±1 | 113±3 | 18±1 | 6.7±0.5 | 529±31 | 54±3 | 3.2±0.2 |
| Female | 8 | 22±1 | 102±2 | 21±1 | 9.5±0.7 | 625±43 | 79±5 | 4.6±0.3 |
| P value* | NS | 0.04 | NS | 0.04 | NS | 0.01 | 0.02 | |
| WT mice | ||||||||
| Male | 12 | 20±1.5 | 89±9 | 17±3 | 3.4±1 | 453±128 | 33±8 | 2.6±0.7 |
| Female | 16 | 17±2 | 78±5 | 16±2 | 4.1±1 | 289±78 | 50±7 | 6.0±1.0 |
| P value* | NS | NS | NS | NS | NS | NS | 0.01 | |
Data are means ± SE. WT, wild-type littermates of transgenic mice; BV/TV, total trabecular bone volume; BS/BV, bone surface/bone volume; ObS/BS, osteoblast surface/bone surface; OcS/BS, osteoclast surface/bone surface; NOb/TAR, number of osteoblasts per total area; NOc/TAR, number of osteoclasts/per total area; NOc/Bpm, number of osteoclasts/per bone perimeter.
*
*Male vs. female mice of a given genotype.