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Greater longevity in rats is associated with lower reactive oxygen species (ROS) production compared with mice. Mitochondrial ROS production in the brain (A), muscle (B), kidney (C), heart (D), and liver (E) is significantly reduced at 24 mo of age in rats compared with mice (n = 4–8, P < 0.05). FCCP, carbonyl cyanide p-trifluormethoxyphenylhydrazone. aSignificant with respect to mice.
