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UCP2 mediates lifespan in sod2−/− mice by controlling ROS production. A: ROS production in embryonic day 18 mouse pups was significantly greater in all SOD2_ucp2−/− genotypes, indicating that the presence of UCP2 helps to neutralize ROS production and promote survival. B: ROS production is significantly suppressed in sod2 +/− and −/− mice overexpressing hUCP2. aSignificant with respect to ucp2+/+ mice. bSignificant with respect to sod2+/+ mice.
