Table 2.

Bone mineral and area parameters of the femur and L₄ vertebral body assessed ex vivo using DXA

	ZDF Comparison			ZDSD vs. Parent Strain
	ZDFfa/+ (n = 12)	ZDFfa/fa (n = 12)	P	Control (nondiabetic)* (n = 12)	ZDSD (n = 17)	P
BMD, g/cm2
Whole femur	0.255±0.006	0.196±0.002	<0.001	0.279±0.008	0.254±0.005	<0.050
Femur midshaft	0.264±0.008	0.211±0.002	<0.001	0.294±0.009	0.280±0.006	0.183
L4 vertebra	0.140±0.002	0.102±0.003	<0.001	0.148±0.004	0.139±0.009	<0.005
BMC, g
Whole femur	0.700±0.036	0.442±0.028	<0.001	0.940±0.032	0.750±0.022	<0.001
Femur midshaft	0.074±0.001	0.054±0.001	<0.001	0.093±0.003	0.083±0.003	<0.050
L4 vertebra	0.097±0.006	0.061±0.002	<0.001	0.108±0.005	0.087±0.003	<0.010
Area, cm2
Whole femur	2.74±0.139	2.25±0.131	<0.001	3.38±0.107	2.95±0.037	<0.001
Femur midshaft	0.283±0.004	0.257±0.004	<0.001	0.294±0.025	0.301±0.004	0.150
L4 vertebra	0.685±0.031	0.561±0.049	<0.050	0.682±0.060	0.668±0.027	0.183

Values are means ± SE. DXA, dual-energy X-ray absorptiometry; BMD, bone mineral density; BMC, bone mineral content. Scanning orientation of vertebral body is the dorsal aspect resting on the imaging stage.

^*Charles River Laboratory:CD rats was used as one of the parent strains to develop the ZDSD rats.