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. 2009 Jan 21;296(4):E765–E774. doi: 10.1152/ajpendo.90937.2008

Table 3.

Cross-sectional structural properties assessed ex vivo by pQCT at the midshaft of the femoral diaphysis

ZDF Comparison
 ZDSD vs. Parent Strain
ZDFfa/+ (n = 12) ZDFfa/fa (n = 12) P Control* (n = 12) ZDSD (n = 17) P
Femur length, mm 41.2±0.1 36.8±0.2 <0.001 44.1 ±0.3 42.3±0.2 <0.001
Geometric data
    Ps.C, mm 13.6±0.3 11.8±0.1 <0.001 14.5±0.2 13.8±0.1 <0.01
    Es.C, mm 7.7±0.2 7.5±0.1 0.700 8.5±0.2 8.4±0.1 0.959
    Ct.Th, mm 0.94±0.02 0.69±0.01 <0.001 0.96±0.02 0.85±0.01 <0.001
    T.Ar, mm2 13.3±0.1 11.2±0.2 <0.001 16.7±0.4 15.2±0.3 <0.010
    Ct.Ar, mm2 8.9±0.1 6.7±0.1 <0.001 11.02±0.3 9.5±0.2 <0.005
    Ip, mm4 24.45±0.48 16.09±0.43 <0.001 39.34±1.94 31.17±1.27 <0.005
    Iy, mm4 14.59±0.32 9.09±0.34 <0.001 23.95±1.27 18.63±0.71 <0.001
Cortical bone mineral data
    vBMD, mg/cm3 1,478±4 1,436±3 <0.001 1,483±3 1,459±2 <0.001
    BMC, mg/mm 13.8±0.2 10.0±0.2 <0.001 16.3±0.4 15.9±0.4 <0.001

Values are means ± SE. pQCT, peripheral quantitative CT; Ps.C, periosteal circumference; Es.C, endosteal circumference; Ct.Th, cortical thickness; T.Ar, total area; Ct.Ar, cortical area; Ip, polar moment of inertia; Iy, cross-sectional moment of inertia perpendicular to axis of mechanical testing; vBMD, volumetric BMD.

*

Charles River Laboratory:CD rats were used as one of the parent strains to develop the ZDSD rats.