Table 5.
Three-dimensional microstructural parameters of the cancellous bone of the L4 vertebral body assessed ex vivo by micro-CT
| ZDF Comparison* |
ZDSD vs. Parent Strain† | |||||
|---|---|---|---|---|---|---|
| ZDFfa/+ (n = 11) | ZDF (n = 12) | P | Control§ (n = 12) | ZDSD (n = 17) | P | |
| L4 Vertebra‡ | ||||||
| BV/TV, % | 25.1±2.2 | 17.4±0.91 | <0.005 | 28.9±2.1 | 21.3±1.1 | <0.005 |
| Tb.N, mm−1 | 2.89±0.11 | 3.00±0.10 | 0.4776 | 3.11±0.13 | 3.01±0.08 | 0.4454 |
| Tb.Th, mm | 0.085±0.003 | 0.062±.001 | <0.0001 | 0.093±0.003 | 0.075±0.002 | <0.0001 |
| Tb.Sp, mm | 0.342±.012 | 0.326±0.010 | 0.3089 | 0.304±0.014 | 0.318±0.008 | 0.3199 |
| Conn.D, mm−3 | 38.65±2.48 | 55.44±5.76 | <0.05 | 40.25±2.32 | 44.86±2.59 | 0.1997 |
| SMI | 0.144±0.214 | 0.794±0.070 | <0.05 | 0.092±0.245 | 0.733±0.140 | <0.05 |
Values are means ± SE for male rats (33 wk old). BV/TV, bone volume (BV) fraction (where TV is tissue volume); Tb.N, trabecular number; Tb.Th, trabecular thickness; Tb.Sp, trabecular separation Conn.D, connectivity density; SMI, structural model index.
*
Thresholded at 38% of maximal gray-scale value.
†
Thresholded at 34% of maximal gray-scale value.
‡
200 slices distal to the cranial growth plate at medium resolution (12 μm).
§
Charles River Laboratory:CD rats were used as one of the parent strains to develop the ZDSD rats.