Fig. 1.
Effect on inflammation on neurally evoked secretion and changes to the epithelial responsiveness to secretagogues. A: noncholinergic secretion elicited by veratridine (10 μM) in the presence of atropine (1 μM) in tissue from control animals, and animals treated 3 and 7 days previously with trinitrobenzene sulfonic acid (TNBS). B: representative traces of veratridine response in control (solid) and 7-day inflamed animals (shaded) in the presence of atropine. Scale bars: 10 μA, 50 s. C: response to vasoactive intestinal peptide (VIP, 30 nM) and the fast peak response to carbachol (CCH, 1 μM) in the presence of tetrodotoxin (TTX, 300 nM). Inset: representative trace of change in short-circuit current (ΔISC) following CCH stimulation. Scale bars: 20 μA, 50 s. *P < 0.05.