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Cumulative concentration-response curves for the dual cyclooxygenases (COXs) inhibitor indomethacin, the selective inhibitor of 5-lipoxygenase (5-LO) NDGA, and vehicle in the IAS of rats. Indomethacin produces a significant decrease in the IAS basal tone (*P < 0.05). NDGA and vehicle do not produce any significant effect (P > 0.05). Data represent means ± SE of 4–9 independent determinations.
