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Time course of the effect of indomethacin or NDGA (both at 100 μM) and the combination of indomethacin plus NDGA on the basal IAS tone. Data show significant (*P < 0.05; n = 4) sustained decrease in the IAS tone with indomethacin alone, whereas NDGA has no significant effect (P > 0.05; n = 4). NDGA administered 5 min following pretreatment with indomethacin causes significant reversal of the suppressed basal tone (**P < 0.05; n = 4).
