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Effect of COX-1 (SC-560; A) and COX-2 (rofecoxib; B) selective inhibitors on the increase in the IAS tone by AA. As shown, SC-560 causes significant and concentration-dependent rightward shift in the AA concentration-response curves (*P < 0.05; n = 4; A). Rofecoxib, on the other hand, has no significant effect (P > 0.05; n = 4; B). These data suggest significant contribution of COX-1 versus COX-2 in AA metabolic pathway in the IAS.
