Fig. 8.

A: relaxation to ACh in aortic ring preparations from 3-, 18-, and 24-mo-old P. leucopus. Data are means ± SE; n = 5 animals/group. B: age-dependent decline in the maximal relaxation responses induced by ACh (open symbols) in aortas of M. musculus and P. leucopus as a function of chronological age. M. musculus data were replotted from previous publications (12, 43). Age-dependent increases in vascular O₂^•− production (as assessed by DHE staining) in arteries of M. musculus and P. leucopus (filled symbols) are superimposed.